Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), ASHP (updated 23 Oct 2020) and others. © 2013 VerticalScope Inc. All rights reserved. Avoid bending the ear when inserting the needle. Two studies, a target animal safety (TAS) study and a pharmacokinetic (PK) study (see CLINICAL PHARMACOLOGY section), were conducted to assess the safety of EXCEDE in the horse. Table 5 summarizes the clinical success rates obtained 15 and 25 days after the first dose. Penicillins and cephalosporins can cause allergic reactions in sensitized individuals. zooepidemicus. Use of antibacterial drugs in the absence of a susceptible bacterial infection is unlikely to provide benefit to treated animals and may increase the risk of the development of drug-resistant bacteria. This is especially true if the medication is applied to a pet’s denuded or fissured areas. Administration of EXCEDE Sterile Suspension in the middle third of the posterior aspect of the ear with or without growth promoting implants was well tolerated by cattle. Considered one of the most used and efficient medicines in veterinary medicine, the antibiotic is indicated for the treatment of internal or external infections of bacterial origin. Disclaimer: Some of the links in this article are affiliate links; we will earn a commision, at no additional cost to you, if you make a purchase through one of our links. EXCEDE reduces the treatment requirements from 10 once or twice daily doses of a comparative antibiotic, such as oral trimethoprim-sulfonamide (TMS), to just two doses. Results from a tissue tolerance study indicated that ceftiofur hydrochloride was well tolerated and produced no systemic toxicity in cattle when administered intramuscularly in the neck and rear leg at a dose of 1.0 mg ceftiofur equivalents/lb (2.2 mg/kg) BW at each injection site. Advantages of Excede include: googletag.defineSlot('/1030735/PetGuide_com_300x90_Spotlight_PETS_Content', [300,125], 'PetGuide_com_300x90_Spotlight_PETS_Content').defineSizeMapping(googletag.sizeMapping().addSize([1024, 10], [300, 125]).addSize([642, 10], [300, 125]).addSize([0, 0], [99999, 99999]).build()).addService(googletag.pubads()); It’s also worth noting that some pets might have an allergic reaction to some of its ingredients. For additional guidance on the proper injection technique and on the availability of needles with a 45° bevel please contact Pfizer Animal Health, Pfizer Canada Inc. at toll-free 1-800-461-0917. In a Mannheimia haemolytica challenge model study, EXCEDE Sterile Suspension administered as a single SC dose in the middle third of the posterior aspect of the ear was shown to be an effective treatment for induced bovine pneumonic pasteurellosis. * The following in vitro data are available but their clinical significance is unknown. Tresaderm’s formula is composed of three paramount components: a corticosteroid, an antifungal, and a broad-spectrum antibiotic that’s effective in a wide variety of conditions. You should keep Tresaderm out of the reach of kids and pets. tmax - the time after initial injection to when Cmax occurs, measured in hours. Ceftiofur has demonstrated in vitro activity against Mannheimia haemolytica, Pasteurella multocida, and Histophilus somni, three major pathogens associated with BRD, and against Fusobacterium necrophorum and Porphyromonas levii associated with bovine foot rot.
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